# Translational Intelligence

> The organizational operating system for building an AI-native biotech. An open, evidence-backed field guide for building an AI-native biotech. From Alexander Titus. Written by Alexander Titus, the author of
> record; the publication is AI-assisted human work product. Corpus version:
> 2026-07-28.

## Machine surfaces

- [Knowledge bundle (full corpus, one Markdown file)](https://translationalintelligence.com/knowledge.md)
- [Full-text RSS feed](https://translationalintelligence.com/rss.xml)
- [Sitemap](https://translationalintelligence.com/sitemap-index.xml)

## The frameworks (canonical pages)

- [Translational Intelligence](https://translationalintelligence.com/translational-intelligence/)
- [Permission, People, Programs](https://translationalintelligence.com/permission-people-programs/)
- [Buy the Record. Build the Intelligence.](https://translationalintelligence.com/buy-record-build-intelligence/)
- [The AI Product Partner](https://translationalintelligence.com/ai-product-partner/)
- [The AI-Native Biotech](https://translationalintelligence.com/ai-native-biotech/)
- [The Scope Ladder](https://translationalintelligence.com/scope-ladder/)

## Artifacts (reusable tools)

- [A Lightweight AI Use Policy](https://translationalintelligence.com/artifacts/ai-use-policy/): One page. Two tiers of data and one ethos, that there is no AI work product, only AI-assisted human work product, and a human is accountable for all of it.
- [How to Write With AI Without Sounding Like It](https://translationalintelligence.com/artifacts/ai-writing-style-guide/): A house style guide for writing with AI. Derive your voice from evidence, state the rules worth stating, and cut the structural tells that make prose sound machine-made.
- [Where AI Touches a Clinical-Stage Biotech](https://translationalintelligence.com/artifacts/clinical-stage-ai-map/): A practical map for the company whose science is at the CROs. Where AI helps across clinical ops, regulatory, medical writing, and vendor oversight, and where the validated-environment line sits.
- [The Build-vs-Buy Decision Framework](https://translationalintelligence.com/artifacts/build-vs-buy/): Route any AI request through five honest options, why the line now leans toward build, the five-year promise that comes with it, and how the smallest builds win the adoption that unlocks the big ones.
- [The First 90 Days](https://translationalintelligence.com/artifacts/first-90-days/): The starter plan for a sub-100-person biotech. Not a roadmap, one quarter you can run that raises your weakest pillar a level, then repeats.
- [The People-First Playbook](https://translationalintelligence.com/artifacts/people-first-playbook/): You cannot deploy a culture. You lead one. The concrete moves for the human side of an AI transformation, the part that actually decides whether it holds.
- [The Permission, People, Programs Scorecard](https://translationalintelligence.com/artifacts/ppp-scorecard/): One page. Grade your company on the three pillars that decide whether AI changes how you work, and find the one to fix first.
- [The Small-Team Operating Model](https://translationalintelligence.com/artifacts/small-team-operating-model/): How a sub-100-person biotech runs an AI transformation without a Head of AI, a platform, or a committee. The fractional version of every role and program.
- [The Think-Harder Writing Workflow](https://translationalintelligence.com/artifacts/think-harder-workflow/): An eight-step method for writing with AI that sharpens your thinking instead of replacing it. Expand before you compress, decide what you believe, and keep the judgment yours.
- [The Day-One Target Safety Triage](https://translationalintelligence.com/artifacts/target-safety-triage/): How to use AI to pull a first-pass target safety read in a day. Not to replace the expert assessment, but to surface a disqualifying signal, for a human to verify, before you spend a scientist's month on a doomed target.
- [The Value Map](https://translationalintelligence.com/artifacts/value-map/): A one-page way to decide where to point AI. Sort your team's work by two values, what the business needs and what only your best people should do, and aim automation at the corner that frees your scarcest talent.

## Issues, FAQs, and Case Studies

- [Issue: The Biotech of Tomorrow](https://translationalintelligence.com/the-biotech-of-tomorrow/)
- [FAQ: Where do I actually start with AI at my biotech?](https://translationalintelligence.com/faqs/where-do-i-start/)
- [Issue: There Is No AI Work Product](https://translationalintelligence.com/there-is-no-ai-work-product/)
- [FAQ: Which pillar should I fix first?](https://translationalintelligence.com/faqs/which-pillar-first/)
- [Issue: Stop Swinging for the Fences](https://translationalintelligence.com/stop-swinging-for-the-fences/)
- [FAQ: How do I tell a real build from rebuilding a commodity?](https://translationalintelligence.com/faqs/real-build-or-commodity/)
- [Issue: Don't Automate the Struggle](https://translationalintelligence.com/dont-automate-the-struggle/)
- [FAQ: Do I hire an AI Product Partner, or grow one?](https://translationalintelligence.com/faqs/hire-or-grow-ai-product-partner/)
- [Issue: Excellent and Generic](https://translationalintelligence.com/excellent-and-generic/)
- [FAQ: Are we AI-native, or just AI-enabled?](https://translationalintelligence.com/faqs/ai-native-or-ai-enabled/)
- [Issue: Your Edge Was Never the Model](https://translationalintelligence.com/your-edge-was-never-the-model/)
- [FAQ: What if legal wants a longer, stricter AI policy?](https://translationalintelligence.com/faqs/longer-stricter-policy/)
- [Issue: The One-Lever Mistake](https://translationalintelligence.com/the-one-lever-mistake/)
- [FAQ: How do I run build-versus-buy in a real meeting?](https://translationalintelligence.com/faqs/run-build-vs-buy-in-a-meeting/)
- [Issue: Arguing About the Wrong Thing](https://translationalintelligence.com/arguing-about-the-wrong-thing/)
- [FAQ: Doesn't thinking with AI make writing slower?](https://translationalintelligence.com/faqs/doesnt-this-make-writing-slower/)
- [Issue: Audit Yourself in Public](https://translationalintelligence.com/audit-yourself-in-public/)
- [FAQ: How do I get AI to write in my voice?](https://translationalintelligence.com/faqs/get-ai-to-write-in-my-voice/)
- [Case Study: Built by Its Own Rules](https://translationalintelligence.com/case-studies/built-by-its-own-rules/)
- [Issue: There Are Only Five Moves](https://translationalintelligence.com/only-five-moves/)
- [FAQ: How do I audit my own company against its own rules?](https://translationalintelligence.com/faqs/how-to-self-audit/)
- [Issue: An Afternoon, or a Restructure](https://translationalintelligence.com/an-afternoon-or-a-restructure/)
- [Issue: You Can't Fix What You Won't Grade](https://translationalintelligence.com/cant-fix-what-you-wont-grade/)
- [FAQ: What's a passing score?](https://translationalintelligence.com/faqs/whats-a-passing-score/)
- [FAQ: Which rung of the ladder should I start on?](https://translationalintelligence.com/faqs/which-rung-should-i-start-on/)
- [Case Study: The Task Was Never the Point](https://translationalintelligence.com/case-studies/the-task-was-never-the-point/)
- [Issue: You Don't Need a Roadmap. You Need a Quarter.](https://translationalintelligence.com/you-dont-need-a-roadmap/)
- [FAQ: What will the first 90 days cost?](https://translationalintelligence.com/faqs/what-will-90-days-cost/)
- [Case Study: Better Than a Blank Page](https://translationalintelligence.com/case-studies/better-than-a-blank-page/)
- [Issue: You Already Employ Your AI Product Partner](https://translationalintelligence.com/already-on-your-team/)
- [FAQ: Who on my team should own AI?](https://translationalintelligence.com/faqs/who-should-own-ai/)
- [Case Study: The 72-Hour Transcript](https://translationalintelligence.com/case-studies/the-72-hour-transcript/)
- [Issue: When Your Science Is Outsourced](https://translationalintelligence.com/when-your-science-is-outsourced/)
- [FAQ: Can I use AI in a validated workflow?](https://translationalintelligence.com/faqs/ai-in-a-validated-workflow/)
- [Case Study: Fifteen Minutes at a Time](https://translationalintelligence.com/case-studies/fifteen-minutes-at-a-time/)
- [Case Study: The Shaping Cone](https://translationalintelligence.com/case-studies/the-shaping-cone/)
- [Issue: Don't Point AI at Your Best Work](https://translationalintelligence.com/dont-point-ai-at-your-best-work/)
- [Issue: The Fast No](https://translationalintelligence.com/the-fast-no/)
- [FAQ: Should I keep AI away from my most important work?](https://translationalintelligence.com/faqs/ai-on-your-best-work/)
- [FAQ: If AI finds no red flag, is the target safe?](https://translationalintelligence.com/faqs/no-red-flag-safe-target/)
- [Issue: A Policy Is Only as Good as It Is Understood](https://translationalintelligence.com/a-policy-is-only-as-good-as-it-is-understood/)
- [Issue: Delete It by Default](https://translationalintelligence.com/delete-it-by-default/)
- [Issue: Don't Default AI to IT](https://translationalintelligence.com/dont-default-ai-to-it/)
- [Issue: People First, or Not at All](https://translationalintelligence.com/people-first/)
- [Issue: No Final Form](https://translationalintelligence.com/no-final-form/)
- [Issue: The Blank Page Is the Expensive Part](https://translationalintelligence.com/the-blank-page-is-the-expensive-part/)
- [Issue: The Product Is Belief](https://translationalintelligence.com/the-product-is-belief/)
- [FAQ: Can I use an AI first draft in a regulated document?](https://translationalintelligence.com/faqs/ai-first-draft-in-a-regulated-document/)
- [FAQ: How do I know I can trust any of this?](https://translationalintelligence.com/faqs/how-do-i-know-i-can-trust-this/)
- [FAQ: How long should we keep AI meeting transcripts?](https://translationalintelligence.com/faqs/how-long-to-keep-ai-transcripts/)
- [FAQ: Isn't efficiency a good place to start?](https://translationalintelligence.com/faqs/isnt-efficiency-a-good-place-to-start/)
- [FAQ: Isn't teaching the whole company the policy too expensive?](https://translationalintelligence.com/faqs/isnt-teaching-the-whole-company-too-expensive/)
- [FAQ: How do I justify a win that doesn't show ROI?](https://translationalintelligence.com/faqs/justify-a-win-without-roi/)
- [FAQ: We have the tools. No one's using them. Now what?](https://translationalintelligence.com/faqs/tools-but-no-adoption/)
- [FAQ: Should AI report to IT?](https://translationalintelligence.com/faqs/should-ai-report-to-it/)
- [Issue: Buying AI Is Easy. Becoming a Different Company Is the Hard Part.](https://translationalintelligence.com/buying-ai-is-easy/)